Sodium Hydroxide → Sodium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

HRID 1479226Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1479226
[CH3:1][C:2]1([CH3:11])[O:6][C@@H:5]([C:7]([O:9]C)=[O:8])[CH2:4][O:3]1.[OH-].[Na+:13]>O1CCOCC1>[CH3:1][C:2]1([CH3:11])[O:6][C@@H:5]([C:7]([O-:9])=[O:8])[CH2:4][O:3]1.[Na+:13]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 853166Methyl (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

Produkt 1

HCID 23717304Sodium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

Methyl (R)-(+)-2,2-dimethyl-1,3-dioxolane-4-carboxylate (1.00 g, 6.2 mmol) was dissolved in 80% aqueous 1,4-dioxane. 1.2 M aqueous NaOH solution was added (5.2 ml) and the reaction mixture was stirred at room temperature for 3 h. After that the solvents were removed under reduced pressure and a colourless solid was obtained (1.03 g, 6.1 mmol, 98%). The product was used immediately in the next reaction step without further purification.

Aufarbeitung

  1. customAfter that the solvents were removed under reduced pressure
  2. customa colourless solid was obtained (1.03 g, 6.1 mmol, 98%)
  3. customThe product was used immediately in the next reaction step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-fe3d4150b1dd41b39523b68e37e4e852
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09408919B2

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