HCID 58455265, compound → HCID 58455270, compound

HRID 1479228Notes

Reaction equation

HRID 1479228 reaction equation
CC1(C)[O:6][CH:5]([C:7]([O:9][C@@H:10]2[CH2:15][C@H:14]([CH3:16])[CH2:13][CH2:12][C@H:11]2[CH:17]([CH3:19])[CH3:18])=[O:8])[CH2:4][O:3]1>C(O)C>[OH:6][CH:5]([CH2:4][OH:3])[C:7]([O:9][C@@H:10]1[CH2:15][C@H:14]([CH3:16])[CH2:13][CH2:12][C@H:11]1[CH:17]([CH3:18])[CH3:19])=[O:8]

Participants

3

Reactant 1

HCID 58455265HCID 58455265, compound

Product 1

HCID 58455270HCID 58455270, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2,2-dimethyl-1,3-dioxolane-4-carboxylate (1.00 g, 35.2 mmol) was dissolved in 98% aqueous ethanol (10 ml). Amberlyst 15 (wet) ion exchange resin (0.30 g) and bumping granulate were added. The reaction mixture was refluxed for 4 h without stirring (under argon). After that, the reaction was brought to room temperature, the resin and bumping granulate were removed and the solvent was removed under reduced pressure. The product was obtained in quantitative yield (0.94 g)

Workup

  1. temperatureThe reaction mixture was refluxed for 4 h
  2. customwas brought to room temperature
  3. customwere removed
  4. customthe solvent was removed under reduced pressure
  5. customThe product was obtained in quantitative yield (0.94 g)

Sources & evidence

ORD record
ord-1416c5f297f242e88ef2053be247bd5c
Source dataset
uspto-grants-2016_08
Patent number
US09408919B2

Reaction notes

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