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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1479279Generated: November 2, 2026

Dimethylamine → (2R)-2-{(3R,6R)-3-(2,3-Dihydro-1H-inden-2-yl)-6-[(1S)-1-methylpropyl]-2,5-dioxo-1-piperazinyl}-2-(2,6-dimethyl-3-pyridinyl)-N-methylethanamide

https://huagongshe.com/reaction/1479279

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylamineHCID 674—
Reactant2-{(3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-6-[(1S)-1-methylpropyl]-2,5-dioxo-1-piperazinyl}-2-(2,6-dimethyl-3-pyridinyl)-N-(2-hydroxyphenyl)acetamideHCID 56949592—
Product(2R)-2-{(3R,6R)-3-(2,3-Dihydro-1H-inden-2-yl)-6-[(1S)-1-methylpropyl]-2,5-dioxo-1-piperazinyl}-2-(2,6-dimethyl-3-pyridinyl)-N-methylethanamideHCID 11705315—

Reaction Steps

Similarly prepared from intermediate 2 and dimethylamine (2.0M in tetrahydrofuran):

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09408851B2
Source datasetuspto-grants-2016_08
ORD IDord-ddfc56604d984336b2d05b14aac0d014
Source noteuspto-grants-2016_08