Isoflurane → Isopropyl Myristate

HRID 1479290Notes

Reaction equation

HRID 1479290 reaction equation
C(Cl)(OC(F)F)C(F)(F)F.CN[C:13]1([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:25]=2Cl)[C:18](=O)[CH2:17][CH2:16][CH2:15][CH2:14]1.CC1C=CC=C(C)C=1NC1SCCCN=1.C[C@@:43]12[C@H:52]3CC[C@:55]4(C)[C:59](=[O:60])[C@H:58](F)[CH2:57][C@H:56]4[C@@H:51]3[CH2:50][CH:49]=[C:48]1[CH2:47]CCC2.[CH2:63]([OH:65])[CH3:64]>>[CH3:47][C:48]1[CH2:43][CH2:52][C@@H:51]([C:56]([CH3:57])=[CH2:55])[CH2:50][CH:49]=1.[C:63]([O:60][CH:59]([CH3:55])[CH3:58])(=[O:65])[CH2:64][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:13][CH2:18][CH2:17][CH2:16][CH2:15][CH3:14]

Participants

6

Reactant 4

HCID 3763IsofluraneHCID 3821KetamineHCID 5707XylazineHCID 131736475HCID 131736475, compound

Product 2

HCID 8042Isopropyl MyristateHCID 440917(+)-Limonene

Procedure

The mice were anesthetized with Isoflurane, and then were given an intramuscular injection of 0.1 mL solution of ketamine (50 mg/kg) and xylazine (10 mg/kg). Approximately 10 minutes after the i.m. injection (after the mice could not turn over when placed on their backs), the mice were treated with 12.3 μL of a 10 mg/mL fluasterone/ethanol:limonene:isopropyl myristate solution to give a dose of 5 mg/kg. The mice were anesthetized and on their backs for approximately 30 minutes after application of fluasterone:ethanol:limonene:isopropyl myristate solution. One hour after the application of fluasterone solution, 2 μg of TPA dissolved in 0.2 mL of acetone was applied to the shaved area on the back of each mouse.

Workup

  1. customApproximately 10 minutes

Sources & evidence

ORD record
ord-4a2d6b30fc7c42c393cc49773f1e1673
Source dataset
uspto-grants-2016_08
Patent number
US09408856B2

Reaction notes

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