HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oleic Acid → trans-1-(tert-Butoxycarbonyl)-3,4-bis(((Z)-octadec-9-enoyloxy)methyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oleic Acid | HCID 445639 | — |
| Reactant | (3S,4S)-tert-Butyl 3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate | HCID 59512458 | — |
| Product | trans-1-(tert-Butoxycarbonyl)-3,4-bis(((Z)-octadec-9-enoyloxy)methyl)pyrrolidine | HCID 86682225 | — |
Reaction Steps
Compound XIII-1 (280 mg, 54.6%) was obtained in the same manner as that in Reference Example 2, by using trans-3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester (156 mg, 0.674 mmol) obtained by using the method described in WO2006/100036 and oleic acid (Tokyo Chemical Industry Co., Ltd.; 419 mg, 1.48 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09408914B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-c9d3143db1374717a4e7b112775fdb49 |
| Source note | uspto-grants-2016_08 |