HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → N-(5,6-dichloropyridin-3-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-Amino-2,3-dichloropyridine | HCID 14595219 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(5,6-dichloropyridin-3-yl)acetamide | HCID 86652352 | — |
Reaction Steps
To a stirred solution of 5,6-dichloropyridin-3-amine (commercially available) and triethyl amine (3 eq) in CH2Cl2 (0.2 M) at 0° C. was added acetyl chloride (2 eq). After stirring at room temperature overnight the reaction mixture was concentrated under vacuum and the resulting crude residue was purified by chromatography (silica gel, 20-50% EtOAc in hexanes) to afford N-(5,6-dichloropyridin-3-yl)acetamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09408907B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-70c462645a8a4d75bb5b8101918567f6 |
| Source note | uspto-grants-2016_08 |