HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl(2-(2-chloroethoxy)ethoxy)dimethylsilane → 2-(4-(2-(2-(Tert-butyldimethylsilyloxy)ethoxy)ethoxy)-2-methylphenethyl)-8-methylbenzo[f][1,7]naphthyridin-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl(2-(2-chloroethoxy)ethoxy)dimethylsilane | HCID 4555750 | — |
| Reactant | 4-(2-(5-Amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl)-3-methylphenol | HCID 58166509 | — |
| Product | 2-(4-(2-(2-(Tert-butyldimethylsilyloxy)ethoxy)ethoxy)-2-methylphenethyl)-8-methylbenzo[f][1,7]naphthyridin-5-amine | HCID 66875193 | — |
Reaction Steps
2-(4-(2-(2-(Tert-butyldimethylsilyloxy)ethoxy)ethoxy)-2-methylphenethyl)-8-methylbenzo[f][1,7]naphthyridin-5-amine was prepared following an analogous procedure to the preparation described for Example 145/Step 1, but using 4-(2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl)-3-methylphenol (from Example 50) with tert-butyl(2-(2-chloroethoxy)ethoxy)dimethylsilane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09408907B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-dc0981f5f7ed445098fd4a791ab06df4 |
| Source note | uspto-grants-2016_08 |