Aluminium lithium hydride → [2-[4-(Trifluoromethoxy)phenyl]-4-pyridyl]methanamine

HRID 1479807Notes

Reaction equation

[F:1][C:2]([F:19])([F:18])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[C:14]([C:16]#[N:17])[CH:13]=[CH:12][N:11]=2)=[CH:6][CH:5]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C(OCC)C>[F:19][C:2]([F:1])([F:18])[O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:15]=[C:14]([CH2:16][NH2:17])[CH:13]=[CH:12][N:11]=2)=[CH:8][CH:9]=1

Participants

Conditions

Temperature: 0 °C

Procedure

A solution of nitrile 20B (3 g, 11.3 mmol) in diethyl ether (30 mL) was added in small amounts to a mixture of LiAlH4 (0.9 g, 2 mol eq) in diethyl ether (35 mL) and stirred at 0° C. After the addition was completed, the mixture was stirred at room temperature overnight. The excess of LiAlH4 was destroyed at 0° C. by addition of small amount of water (30 mL), the solid formed was filtered off and the organic filtrate separated, washed with brine (50 mL) and dried over Na2SO4. The organic phase was evaporated under reduced pressure to obtain 21B as a yellow oil (3.1 g, quantitative yield). 1HNMR (DMSO, 200 MHz) δ 308 (s, 2H), 3.8 (bs, 2H), 7.33 (dd, 1H, J=1.8), 7.47 (dd, 2H, J=2), 7.96 (s, 1H), 8.20 (dd, 2H, J=1.8), 8.57 (dd, 1H, J=1.2).

Workup

additionAfter the addition
stirringthe mixture was stirred at room temperature overnight
customThe excess of LiAlH4 was destroyed at 0° C. by addition of small amount of water (30 mL)
customthe solid formed
filtrationwas filtered off
customthe organic filtrate separated
washwashed with brine (50 mL)
dry with materialdried over Na2SO4
customThe organic phase was evaporated under reduced pressure

Sources & evidence

ORD record: ord-3a9697bed66d4fb89059ef1458d47826
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09409864B2

Reaction notes

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