2,6-Bis(4-(trifluoromethyl)phenyl)-4-pyridinecarbonitrile → [2,6-Bis[4-(trifluoromethyl)phenyl]-4-pyridyl]methanamine

Participants

Reaction Conditions

Reaction Steps

The nitrile 28A (4.7 g, 12 mmol) dissolved in 50 ml of diethyl ether was added dropwise to a mixture of LiAlH4 (912 mg, 2 equiv.) in diethyl ether (80 mL) stirred at 0° C. Then the mixture was stirred at room temperature overnight. The excess of LiAlH4 was destroyed by water addition at 0° C., the solid formed was filtered, washed with Et2O and the filtrate was dried over Na2SO4 and evaporated to dryness to obtain 2.5 g of the amine 29A as yellow solid. Yield=52% 1HNMR (DMSO, 400 MHz) δ 2.25 (2H, bs), 3.90 (2H, s), 7.90 (4H, d, J=8 Hz), 8.11 (2H, s), 8.40 (4H, d, J=8 Hz)

Provenance & Evidence