Iodoethane → HCID 131736592, compound

Participants

Reaction Steps

Compound 9A (1 g, 3.0 mmol) dissolved in DMF (10 ml) was added with K2CO3 (1.1 equiv., 456 mg) and ethyl iodide (1.1 equiv., 0.316 ml) and the reaction was stirred at rt overnight. The reaction was diluted with ethyl acetate and washed several times with water and finally with Brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by crystallization from ethyl ether and petroleum ether afforded 895 mg of a semisolid. Yield=93%. 1HNMR (DMSO, 200 MHz) δ 1.13 (3H, d, J=6.2 Hz), 1.26 (3H, t, J=7 Hz), 3.32 (3H, s), 3.41 (2H, q, J=7.8 Hz), 4.02 (1H, bs), 4.23 (1H, m), 5.13 (1H, d, J=4.6 Hz), 7.42 (2H, m), 7.84 (2H, m)

Provenance & Evidence