Iodoethane → HCID 90384137, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 16 (2 g, 6.7 mmol) in DMF (20 mL) was added with an. K2CO3 (1.5 mol eq, 1.4 g) and, after few minutes, 2-iodoethane (1.2 mol eq, 0.84 ml) was added and the mixture was heated at 50° C. for 4 h. The solvent was removed under reduced pressure, water was added to the residue (100 mL) and the aqueous phase was extracted with EtOAc (3×50 mL). The combined organic phases were dried over Na2SO4 and evaporated under reduced pressure to afford 17 as a pale yellow oil (2.1 g, 95% yield). 1HNMR (DMSO, 200 MHz) δ 1.18 (m, 2H), 1.25 (t, 3H), 1.37 (m, 2H), 1.98 (s, 3H), 3.45 (m, 2H), 7.28 (d, 1H, J=4), 7.78 (d, 1H, J=3.9)

Provenance & Evidence