Diethyl Pyrocarbonate → HCID 90390561, compound

Participants

Reaction Steps

A solution of acid 4B (273.28 mg, 1 mmol) in THF (10 mL) was added with DEPC (0.15 mL, 1.1 mol eq) and the mixture was stirred at room temperature for about 5 minutes. Then [2-[4-(cyclopropylmethyl)piperazin-1-yl]-6-[4-(trifluoromethoxy)phenyl]-4-pyridyl]methanamine 27F (405 mg, 1.04 mol eq) and a catalytic amount of TEA were added, then the reaction mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure, the residue was suspended in EtOAc (40 mL) and washed with water (50 mL) and brine. The separated organic phase was dried over Na2SO4 and evaporated under reduced pressure and the residue was purified by flash chromatography (9:1 EtOAc:methanol) to afford a white solid (200 mg) after crystallization from diethyl ether. Yield=30%, 1HNMR (DMSO, 200 MHz) δ 0.05 (m, 2H), 0.45 (bm, 2H), 0.82 (m, 1H), 1.08 (t, 3H), 2.17 (d, 2H, J=6.4), 3.34 (bm, 4H), 3.49 (bm, 4H), 4.43 (d, 2H, J=6.2), 5.13 (s, 1H); 6.09 (s, 1H), 6.80 (s, 1H), 7.30 (s, 1H), 7.47 (m, 4H), 7.85 (m, 4H), 8.74 (t, 1H). [M+1] 662.90 (C32H35F4N5O4S requires 661.71).

Provenance & Evidence