4-Methylbenzaldehyde → HCID 82019740, compound

Participants

Reaction Steps

To a solution of 4-methylbenzaldehyde (4.38 g, 36 mmol) in 130 mL of acetonitrile at room temperature, 1-(2-methoxyphenyl)methanamine (5 g, 36 mmol) and trimethylsilyl cyanide (5.2 mL, 50 mmol) were added. The mixture was stirred for 16 h at room temperature until the starting materials had been completely consumed as judged by TLC (petroleum ether/ethyl acetate 90:10) and GC analysis. The mixture was quenched with 40 mL of saturated ammonium chloride, stirred for 15 min, added with 100 mL of water and then extracted with ethyl acetate (2×50 mL). The combined organic layers were dried over Na2SO4, filtered and the solvent was removed under reduced pressure. The residue was purified by flash chromatography on silica gel (petroleum ether/ethyl acetate 90:10) to afford [(2-methoxybenzyl)amino](4-methylphenyl)acetonitrile as a red oil (6.1 g, y=64%). 1H NMR (CDCl3) δ (ppm): 7.45 (d, 2H, J=7.3 Hz), 7.33-7.25 (m, 2H), 7.21 (d, 2H, J=7.2 Hz), 6.91-6.85 (m, 2H), 4.79 (s, 1H), 4.03 (d, 1H, J=13.2 Hz), 3.95 (d, 1H, J=13.2 Hz), 3.86 (s, 3H), 2.38 (s, 3H). MS (ES1+) m/z: 266.85 (M+1), 240.04 (M-HCN+1).

Provenance & Evidence