tert-butyl (2S)-2-amino-3-phenylpropanoate → HCID 68174272, compound

Participants

Reaction Steps

Following the 6a synthetic method, using B1 (55.33 mg, 0.25 mmol) instead of A1 gave 6b as a white powder; (88.78 mg, 91.1%). [α]D25: +16.5 (c=0.29, CHCl3); 1H-NMR (300 MHz, CDCl3): δ 8.79 (s, 1H), 7.68 (d, J=9.0 Hz, 1H), 7.59 (d, J=7.2 Hz, 1H), 7.34-7.23 (m, 6H), 7.07 (dd, J=2.4, 9.0 Hz, 1H), 5.18-5.12 (m, 1H), 3.89 (s, 3H), 3.43-3.28 (m, 2H); 13C NMR (300 MHz, CDCl3): δ 175.50, 160.91, 159.94, 140.08, 135.36, 132.54, 130.83, 129.51, 128.97, 128.76, 127.41, 124.12, 119.87, 116.45, 113.99, 104.31, 55.71, 54.06, 37.36; HRMS (ESI): calcd for: C19H16ClNO4S [M−H]−=388.0416, obsd [M−H]−=388.0402.

Provenance & Evidence