tert-butyl (2S)-2-amino-3-phenylpropanoate → HCID 25625244, compound

Participants

Reaction Steps

Following the 10a synthetic method, using B1 (110.65 mg, 0.5 mmol) instead of A1 gave 10b as a white powder; (163.96 mg, 95.5%). [α]D25: +21.8 (c=0.35, CHCl3); 1H-NMR (300 MHz, CDCl3): δ 7.97 (s, 1H), 7.74-7.69 (m, 1H), 7.60 (s, 1H), 7.39-7.16 (m, 7H), 6.86 (d, J=7.5 Hz, 1H), 5.09-5.07 (m, 1H), 3.39-3.22 (m, 2H); 13C NMR (300 MHz, CDCl3): δ 175.03, 162.49, 162.17, 159.27, 139.84, 139.51, 136.42, 135.52, 129.37, 128.76, 127.36, 125.57, 124.05, 115.93, 110.45, 53.87, 37.31; HRMS (ESI): calcd for: C18H14FNO3S [M−H]−=342.0606, obsd [M−H]−=342.0596.

Provenance & Evidence