tert-butyl (2S)-2-amino-3-phenylpropanoate → HCID 68174277, compound

Participants

Reaction Steps

Following the 11a synthetic method, using B1 (110.65 mg, 0.5 mmol) instead of A1 gave 11b as a colorless oil; (164.98 mg, 91.7%). [α]D25: +23.3 (c=0.42, CHCl3); 1H-NMR (300 MHz, acetone-d6): δ 8.06-8.00 (m, 1H), 7.91-7.87 (m, 1H), 7.80 (d, J=6.9 Hz, 1H), 7.62-7.55 (m, 2H), 7.37-7.22 (m, 5H), 5.05-4.98 (m, 1H), 3.45-3.26 (m, 2H); 13C NMR (300 MHz, acetone-d6): δ 171.56, 159.74, 137.75, 136.74, 136.67, 132.78, 129.51, 128.40, 127.67, 126.88, 125.74, 123.03, 122.83, 118.86, 54.09, 36.83; HRMS (ESI): calcd for: C18H14ClNO3S [M−H]−=358.0310, obsd [M−H]−=358.0312.

Provenance & Evidence