2-Fluorobenzenesulphonyl chloride → HCID 59054573, compound

Participants

Reaction Steps

Following 17a synthetic method, using 2-fluorobenzenesulfonyl chloride (145.62 μL, 1.1 mmol) instead of 2-fluorobenzenesulfonyl chloride gave the final compound 18a as a colorless oil; (77.34 mg, 45.6%). [α]D25: +21.3 (c=0.25, CHCl3); 1H-NMR (300 MHz, acetone-d6): δ 7.95-7.76 (m, 3H), 7.41-7.25 (m, 6H), 5.04-4.97 (m, 1H), 3.45-2.26 (m, 2H); 13C NMR (300 MHz, acetone-d6): δ 171.50, 163.90, 160.62, 139.15, 136.64, 133.50, 129.49, 128.40, 126.89, 124.94, 118.56, 115.15, 109.30, 54.04, 36.79; HRMS (ESI): calcd for: C15H14FNO5S [M+Na]+=362.0469, obsd [M+Na]+=362.0475.

Provenance & Evidence