L-Tyrosine 1,1-dimethylethyl ester → HCID 68174317, compound

Participants

Reaction Steps

Following 18a synthetic method, using B2 (118.65 mg, 0.5 mmol) instead of A2 gave 18b as a colorless oil; (56.33 mg, 49.8%). [α]D25: −14.4 (c=0.27, CHCl3); 1H-NMR (300 MHz, acetone-d6): δ 8.20 (s, 1H), 7.56-7.48 (m, 2H), 7.44-7.35 (m, 2H), 7.03-6.95 (m, 3H), 6.70-6.65 (m, 2H), 4.18-4.11 (m, 1H), 3.06-2.81 (m, 2H); 13C NMR (300 MHz, acetone-d6): δ 171.53, 163.77, 160.48, 156.28, 143.54, 131.00, 130.36, 126.92, 122.75, 119.25, 115.07, 113.89, 113.57, 57.63, 37.74; HRMS (ESI): calcd for: C15H14FNO5S [M+Na]+=362.0469, obsd [M+Na]+=362.0485.

Provenance & Evidence