L-Tyrosine 1,1-dimethylethyl ester → HCID 40492103, compound

Participants

Reaction Steps

Following 19a synthetic method, using B2 (118.65 mg, 0.5 mmol) instead of A2 gave 19b as a colorless oil; (96.03 mg, 56.6%). [α]D25: −13.7 (c=0.23, CHCl3); 1H-NMR (300 MHz, CDCl3): δ 7.78-7.71 (m, 2H), 7.26-7.17 (m, 7H), 6.92 (d, J=9 Hz, 1H), 4.25-4.13 (m, 1H), 3.15-2.90 (m, 2H); 13C NMR (300 MHz, acetone-d6): δ 171.56, 166.28, 162.95, 137.52, 136.53, 129.74, 129.62, 129.39, 128.24, 126.68, 115.94, 115.63, 57.31, 38.48; HRMS (ESI): calcd for: C15H14FNO4S [M+Na]+=346.0520, obsd [M+Na]+=346.0523.

Provenance & Evidence