3-Bromo-6-chloroimidazo(1,2-b)pyridazine → HCID 71491985, compound

HRID 1479940Notes

Reaction equation

HRID 1479940 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:11]3[O:19][C:18]4[C:13](=NC=[CH:16][CH:17]=4)[CH:12]=3)=[CH:9][N:10]=2)[N:7]=1.BrC1N2N=C(Cl)C=CC2=[N:23][CH:22]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:11]3[O:19][C:18]4[CH:17]=[CH:16][N:23]=[CH:22][C:13]=4[CH:12]=3)=[CH:9][N:10]=2)[N:7]=1

Participants

3

Reactant 2

HCID 128723233-Bromo-6-chloroimidazo(1,2-b)pyridazineHCID 71491984HCID 71491984, compound

Product 1

HCID 71491985HCID 71491985, compound

Procedure

6-Chloro-3-(furo[3,2-c]pyridin-2-yl)imidazo[1,2-b]pyridazine was prepared in analogy to 6-chloro-3-(furo[3,2-b]pyridin-2-yl)imidazo[1,2-b]pyridazine starting from 314 mg (1.35 mmol) of 3-bromo-6-chloroimidazo[1,2-b]pyridazine to yield 62% of a solid material.

Sources & evidence

ORD record
ord-e77e43c136a94741a679ca75b82367fc
Source dataset
uspto-grants-2016_08
Patent number
US09409889B2

Reaction notes

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