反应详情

To a solution of example 6 (0.74 g, 1.31 mmol) and methanol (10 mL) is added sodium hydroxide (100 mg). The mixture is stirred at room temperature overnight. Solvent is removed and the residue is dissolved in water and acidified with 3 N HCl to pH about 7, and extracted with ethyl acetate. The ethyl acetate layer is concentrated to afford the title compound (0.68 g, 96%) as a yellow solid.

1. customSolvent is removed
2. dissolutionthe residue is dissolved in water
3. extractionextracted with ethyl acetate
4. concentrationThe ethyl acetate layer is concentrated