反应详情

To a solution of 3-benzyl-4,5-dimethyl-6-(1-(5-(trifluoromethyl)pyridin-2-yl)-1,2,3,6-tetrahydropyridin-4-yl)pyridazine (20 mg, 0.047 mmol) in 8 mL EtOH is added 10% Pd—C (25 mg, 19 mmol). The reaction mixture is stirred under hydrogen atmosphere for 16 h. The mixture is filtered throug Celite and the filtrate is concentrated to afford a off-white solid. The mixture is purified by prep HPLC, eluting with 10%-100% acetonitrile:water (both mobile phases modified by 3% n-PrOH). Fractions containing the desired product are combined and freeze-dried to afford a white solid (8 mg, 40%).

1. filtrationThe mixture is filtered throug Celite
2. concentrationthe filtrate is concentrated
3. customto afford a off-white solid
4. customThe mixture is purified by prep HPLC
5. washeluting with 10%-100% acetonitrile
6. additionFractions containing the desired product
7. customfreeze-dried