Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Methyl 5-chloropyrazine-2-carboxylate | HCID 406081 | — |
| Reactant | tert-Butyl (2R)-2-methylpiperazine-1-carboxylate | HCID 10262201 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67179448 | HCID 67179448 | — |
Reaction Steps
To (R)-1-boc-methylpiperazine (1 g, 5.0 mmol) in DMF (20 mL) is added 5-chloro-pyrazine-2-carboxylic acid methyl ester (862 mg, 5.0 mmol) and Na2CO3 (2.1 g, 20.0 mmol). The reaction mixture is stirred in a microwave reactor at 140° C. for 3 h. Then the mixture is cooled to rt and the organic solvent is removed in vacuo to afford a brown colored solid as product (1.7 g, quant.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09409871B2 |
|---|
| Source dataset | uspto-grants-2016_08 |
|---|
| ORD ID | ord-ced445136e534fd789b7d1eb79656e6e |
|---|
| Source note | uspto-grants-2016_08 |
|---|
