2-Methylpiperazine, (R)- → HCID 59191630, compound

HRID 1479961Notes

Reaction equation

HRID 1479961 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)=[O:9])=[C:4]([CH3:16])[C:3]=1[CH3:17].[CH3:18][C@@H:19]1[CH2:24][NH:23][CH2:22][CH2:21][NH:20]1>>[CH3:16][C:4]1[C:3]([CH3:17])=[C:2]([N:23]2[CH2:22][CH2:21][NH:20][C@H:19]([CH3:18])[CH2:24]2)[N:7]=[N:6][C:5]=1[C:8]([C:10]1[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=1)=[O:9]

Participants

3

Reactant 2

HCID 73304342-Methylpiperazine, (R)-HCID 59191523HCID 59191523, compound

Product 1

HCID 59191630HCID 59191630, compoundYield 83%

Procedure

According to the protocol described below, (6-chloro-4,5-dimethyl-pyridazin-3-yl)-pyridin-4-yl-methanone (750 mg, 3.03 mmol) and (R)-2-methyl-piperazine (364 mg, 3.63 mmol) afforded the title compound as a beige solid (778 mg, 83%).

Sources & evidence

ORD record
ord-5528130c330648b78ecb5685088e2e5a
Source dataset
uspto-grants-2016_08
Patent number
US09409871B2

Reaction notes

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