Ethylamine → HCID 121393712, compound

Participants

Reaction Steps

4-Nitrophenyl chloroformate (226 mg, 1.12 mmol) was added portion wise to a solution of 4-(5-{5-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-2,3-dihydro-1H-imidazol-4-yl}-1H-pyrazol-1-yl)benzonitrile (Example 1) (409 mg, 1.0 mmol) and triethylamine (0.355 mL, 2.55 mmol) in DCM (12 mL) under a nitrogen atmosphere. The mixture was stirred for 2.75 h giving a yellow solution. A solution of ethylamine (3.0 mL of a 2M solution in THF, 6 mmol) was added. The mixture was stirred for a further 2.5 h then concentrated in vacuo. The residue was chromatographed on silica gel eluting with 10-40% EtOAc in DCM then recolumned on silica gel with 25-60% EtOAc in cyclohexane to afford the title compound as a colourless foam after drying in vacuo.

Provenance & Evidence