Trifluoroacetic acid → HCID 121393726, compound

Participants

Reaction Steps

tert-Butyl-{5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-4-methyl-2-oxo-3-[3-(trifluoromethyl)phenyl]-2,3-dihydro-1H-imidazol-1-yl}acetate (Example 20) (75 mg, 0.143 mmol) was stirred in DCM (3 mL) and water (0.03 mL). To this mixture was added TFA (0.1 mL) and the mixture stirred overnight. Reaction was incomplete so further TFA (0.5 mL) was added and after 1 h 30 minutes, a further 1 ml was added. After 4 h reaction was complete, solvents were evaporated and the residue partitioned between EtOAc and water. The organic phase was separated, dried over Na2SO4 and evaporated to give the title compound as a gum.

Provenance & Evidence