Leucinamide → HCID 90214911, compound

HRID 1480049Notes

Reaction equation

[Br:1][C:2]1[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:16][C@@H:17]([CH2:21][CH:22]([CH3:24])[CH3:23])[C:18]([NH2:20])=[O:19]>>[C:18]([C@@H:17]([NH:16][C:8]([C:5]1[CH:4]=[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)[C:2]([Br:1])=[CH:7][N:6]=1)=[O:10])[CH2:21][CH:22]([CH3:24])[CH3:23])(=[O:19])[NH2:20]

Participants

Reactant 2

HCID 69640Leucinamide

HCID 90204264HCID 90204264, compound

Product 1

HCID 90214911HCID 90214911, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 5-bromo-4-(cyclopropylmethoxy)picolinic acid and (2S)-2-amino-4-methyl-pentanamide (CAN 687-51-4) as starting materials and isolated (16 mg, 47%) as yellow oil; MS (ESI, m/z): 385.9 (MH+).

Workup

customisolated (16 mg, 47%) as yellow oil

Sources & evidence

ORD record: ord-5239e5199b3b4294b00339cc6bf6e13c
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09409866B2

Reaction notes

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