HuagongsheHuagongshe Chemistry Print Report · For research reference only
D-Valinol → 5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid ((R)-1-hydroxymethyl-2-methyl-propyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | D-Valinol | HCID 6950587 | — |
| Reactant | 5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid | HCID 90203638 | — |
| Product | 5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid ((R)-1-hydroxymethyl-2-methyl-propyl)-amide | HCID 76282483 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and (2R)-2-amino-3-methyl-1-butanol (CAN 4276-09-9) as starting materials and isolated (51 mg, 54%) as colorless oil; MS (ESI, m/z): 313.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-08fee72d8d5d4a3686d1a9c5f55b685f |
| Source note | uspto-grants-2016_08 |