HuagongsheHuagongshe Chemistry Print Report · For research reference only
R-2-Amino-2,3-dimethyl-butan-1-OL → 5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid ((R)-1-hydroxymethyl-1,2-dimethyl-propyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | R-2-Amino-2,3-dimethyl-butan-1-OL | HCID 12113027 | — |
| Reactant | 5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid | HCID 90203638 | — |
| Product | 5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid ((R)-1-hydroxymethyl-1,2-dimethyl-propyl)-amide | HCID 76282481 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and (2R)-2-amino-2,3-dimethyl-1-butanol (CAN 155158-75-1) as starting materials and isolated (19 mg, 19%) as colorless oil; LC-MS (UV peak area, m/z) 98.6%, 327.1464 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-1b805bad4cd64ea2b2bcb3328f3c0da6 |
| Source note | uspto-grants-2016_08 |