1-Propanol, 3-amino-2,2-dimethyl- → HCID 76282478, compound

HRID 1480062Notes

Reaction equation

HRID 1480062 reaction equation
[Cl:1][C:2]1[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:16][CH2:17][C:18]([CH3:22])([CH3:21])[CH2:19][OH:20]>>[OH:20][CH2:19][C:18]([CH3:22])([CH3:21])[CH2:17][NH:16][C:8]([C:5]1[CH:4]=[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)[C:2]([Cl:1])=[CH:7][N:6]=1)=[O:10]

Participants

3

Reactant 2

HCID 1173261-Propanol, 3-amino-2,2-dimethyl-HCID 902036385-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 76282478HCID 76282478, compound

Procedure

The title compound was synthesized in analogy to Example 12d, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and 3-amino-2,2-dimethyl-1-propanol (CAN 26734-09-8) as starting materials and isolated (23 mg, 74%) as colorless oil; LC-MS (UV peak area, m/z) 100%, 313.1315 (MH+).

Workup

  1. customisolated (23 mg, 74%) as colorless oil

Sources & evidence

ORD record
ord-0815f365da7145d59e396b6c09372fcf
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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