3-Amino-4-methylpentan-1-ol → HCID 76282251, compound

HRID 1480063Notes

Reaction equation

HRID 1480063 reaction equation
[Cl:1][C:2]1[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:16][CH:17]([CH:21]([CH3:23])[CH3:22])[CH2:18][CH2:19][OH:20]>>[OH:20][CH2:19][CH2:18][CH:17]([NH:16][C:8]([C:5]1[CH:4]=[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)[C:2]([Cl:1])=[CH:7][N:6]=1)=[O:10])[CH:21]([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 170394293-Amino-4-methylpentan-1-olHCID 902036385-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 76282251HCID 76282251, compound

Procedure

The title compound was synthesized in analogy to Example 12d, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and 3-amino-4-methyl-1-pentanol (CAN 26734-09-8) as starting materials and isolated (21 mg, 64%) as colorless oil; LC-MS (UV peak area, m/z) 100%, 327.1473 (MH+).

Workup

  1. customisolated (21 mg, 64%) as colorless oil

Sources & evidence

ORD record
ord-bab1927abdcb42fc9fc38e9033d3bf48
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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