HCID 24729719, compound → HCID 76282246, compound

HRID 1480064Notes

Reaction equation

HRID 1480064 reaction equation
[Cl:1][C:2]1[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:16][CH:17]([CH:21]1[CH2:23][CH2:22]1)[CH2:18][CH2:19][OH:20]>>[CH:21]1([CH:17]([NH:16][C:8]([C:5]2[CH:4]=[C:3]([O:11][CH2:12][CH:13]3[CH2:15][CH2:14]3)[C:2]([Cl:1])=[CH:7][N:6]=2)=[O:10])[CH2:18][CH2:19][OH:20])[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 24729719HCID 24729719, compoundHCID 902036385-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 76282246HCID 76282246, compound

Procedure

The title compound was synthesized in analogy to Example 12d, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and γ-amino-cyclopropanepropanol (CAN 683220-79-3) as starting materials and isolated (27 mg, 83%) as colorless oil; LC-MS (UV peak area, m/z) 97.6%, 325.1313 (MH+).

Workup

  1. customisolated (27 mg, 83%) as colorless oil

Sources & evidence

ORD record
ord-c8af8d7654c141a6beef7d17850a6adf
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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