HCID 26249012, compound → HCID 76282248, compound

HRID 1480067Notes

Reaction equation

HRID 1480067 reaction equation
[Cl:1][C:2]1[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[F:16][C:17]([F:27])([F:26])[C@H:18]([C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1)[NH2:19]>>[F:27][C:17]([F:16])([F:26])[C@@H:18]([NH:19][C:8]([C:5]1[CH:4]=[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)[C:2]([Cl:1])=[CH:7][N:6]=1)=[O:10])[C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 26249012HCID 26249012, compoundHCID 902036385-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 76282248HCID 76282248, compound

Procedure

The title compound was synthesized in analogy to Example 12d, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and (αS)-α-(trifluoromethyl)-3-pyridinemethanamine (CAN 749839-26-7) as starting materials and isolated (21 mg, 54%) as colorless oil; LC-MS (m/z), 386.0870 (MH+).

Workup

  1. customisolated (21 mg, 54%) as colorless oil

Sources & evidence

ORD record
ord-372b21e93ca44c7bb4e213786b5482f4
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

Loading…