2-amino-2,4-dimethylpentan-1-ol → HCID 76282479, compound

HRID 1480074Notes

Reaction equation

HRID 1480074 reaction equation
[Cl:1][C:2]1[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:16][C:17]([CH3:24])([CH2:20][CH:21]([CH3:23])[CH3:22])[CH2:18][OH:19]>>[OH:19][CH2:18][C:17]([NH:16][C:8]([C:5]1[CH:4]=[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)[C:2]([Cl:1])=[CH:7][N:6]=1)=[O:10])([CH3:24])[CH2:20][CH:21]([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 220967012-amino-2,4-dimethylpentan-1-olHCID 902036385-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 76282479HCID 76282479, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and 2-amino-2,4-dimethyl-1-pentanol (CAN 13893-55-5) as starting materials and isolated (193 mg, quant.) as colorless oil; LC-MS (UV peak area, m/z) 100%, 341.1623 (MH+).

Workup

  1. customisolated (193 mg, quant.) as colorless oil

Sources & evidence

ORD record
ord-b3ac85c93d504da3a1d93870d7f65b3a
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

Loading…