HCID 55288706, compound → HCID 90203902, compound

HRID 1480077Notes

Reaction equation

HRID 1480077 reaction equation
[Cl:1][C:2]1[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH3:16][O:17][C:18](=[O:25])[CH:19]([CH3:24])[C:20]([NH2:23])([CH3:22])[CH3:21]>>[Cl:1][C:2]1[C:3]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)=[CH:4][C:5]([C:8]([NH:23][C:20]([CH3:22])([CH3:21])[CH:19]([CH3:24])[C:18]([O:17][CH3:16])=[O:25])=[O:10])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 55288706HCID 55288706, compoundHCID 902036385-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 90203902HCID 90203902, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and 3-amino-2,3-dimethyl-butanoic acid methyl ester (CAN 89855-37-8) as starting materials and isolated (126 mg, 81%) as colorless oil; LC-MS (UV peak area, m/z) 100%, 355.1427 (MH+).

Workup

  1. customisolated (126 mg, 81%) as colorless oil

Sources & evidence

ORD record
ord-3a9410b4336c46e6a1bb9e54315e78fa
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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