2,2-Dimethyl-1-thiazol-2-yl-propylamine → 5-Chloro-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (2,2-dimethyl-1-thiazol-2-yl-propyl)-amide

HRID 1480082Notes

Reaction equation

HRID 1480082 reaction equation
[Cl:1][C:2]1[C:3]([O:11][CH2:12][C:13]([F:16])([F:15])[F:14])=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH3:17][C:18]([CH3:27])([CH3:26])[CH:19]([NH2:25])[C:20]1[S:21][CH:22]=[CH:23][N:24]=1>>[CH3:17][C:18]([CH3:27])([CH3:26])[CH:19]([NH:25][C:8]([C:5]1[CH:4]=[C:3]([O:11][CH2:12][C:13]([F:16])([F:15])[F:14])[C:2]([Cl:1])=[CH:7][N:6]=1)=[O:10])[C:20]1[S:21][CH:22]=[CH:23][N:24]=1

Participants

3

Reactant 2

HCID 207955242,2-Dimethyl-1-thiazol-2-yl-propylamineHCID 902040145-Chloro-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 762832125-Chloro-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (2,2-dimethyl-1-thiazol-2-yl-propyl)-amide

Procedure

The title compound was synthesized in analogy to Example 24d, using 5-Chloro-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 24c) and 2,2-Dimethyl-1-thiazol-2-yl-propylamine (CAN 1247122-26-4) as starting materials and isolated (72 mg, 51%) as white solid; MS (ESI, m/z): 408.3 (M+H+).

Workup

  1. customisolated (72 mg, 51%) as white solid

Sources & evidence

ORD record
ord-aedf81e4d79849bab9d26af08475af92
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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