HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2,2,2-Trifluoro-1-(pyridin-3-YL)ethanamine hydrochloride → 5-Chloro-4-(4-fluoro-benzyl)-pyridine-2-carboxylic acid ((S)-2,2,2-trifluoro-1-pyridin-3-yl-ethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2,2,2-Trifluoro-1-(pyridin-3-YL)ethanamine hydrochloride | HCID 51358484 | — |
| Reactant | 5-Chloro-4-(4-fluorobenzyl)-pyridine-2-carboxylic acid | HCID 90204124 | — |
| Product | 5-Chloro-4-(4-fluoro-benzyl)-pyridine-2-carboxylic acid ((S)-2,2,2-trifluoro-1-pyridin-3-yl-ethyl)-amide | HCID 76282970 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 12d, using 5-chloro-4-(4-fluorobenzyl)-pyridine-2-carboxylic acid and (αS)-α-(trifluoromethyl)-3-pyridinemethanamine hydrochloride (1:1) (CAN 749839-26-7) as starting materials and isolated (23 mg, 71%) as colorless oil; MS (ESI, m/z): 424.2 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-6cd46e1ad35d47fdbea3b1d111e4a2ce |
| Source note | uspto-grants-2016_08 |