2,2-Dimethyl-1-thiazol-2-yl-propylamine → 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (2,2-dimethyl-1-thiazol-2-yl-propyl)-amide

HRID 1480103Notes

Reaction equation

HRID 1480103 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[CH3:19][C:20]([CH3:29])([CH3:28])[CH:21]([NH2:27])[C:22]1[S:23][CH:24]=[CH:25][N:26]=1>>[CH3:19][C:20]([CH3:29])([CH3:28])[CH:21]([NH:27][C:10]([C:7]1[CH:6]=[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:12])[C:22]1[S:23][CH:24]=[CH:25][N:26]=1

Participants

3

Reactant 2

HCID 207955242,2-Dimethyl-1-thiazol-2-yl-propylamineHCID 902036745-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 902149275-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (2,2-dimethyl-1-thiazol-2-yl-propyl)-amide

Procedure

The title compound was synthesized in analogy to Example 24d, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 48c) and 2,2-Dimethyl-1-thiazol-2-yl-propylamine (CAN 1247122-26-4) as starting materials and isolated (15 mg, 32%) as a white solid; MS (ESI, m/z): 414.5 (M+H+).

Workup

  1. customisolated (15 mg, 32%) as a white solid

Sources & evidence

ORD record
ord-2edc340e83584f58beb74f93537f1f72
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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