2,2,2-Trifluoro-1-(pyridin-2-yl)ethan-1-amine → 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (2,2,2-trifluoro-1-pyridin-2-yl-ethyl)-amide

HRID 1480104Notes

Reaction equation

HRID 1480104 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[F:19][C:20]([F:30])([F:29])[CH:21]([NH2:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1>>[F:30][C:20]([F:19])([F:29])[CH:21]([NH:28][C:10]([C:7]1[CH:6]=[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:12])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1

Participants

3

Reactant 2

HCID 252199112,2,2-Trifluoro-1-(pyridin-2-yl)ethan-1-amineHCID 902036745-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 902149365-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (2,2,2-trifluoro-1-pyridin-2-yl-ethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 24d, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 48c) and 2,2,2-Trifluoro-1-pyridin-2-yl-ethylamine (CAN 503173-14-6) as starting materials and isolated (17 mg, 26%) as a white solid; MS (ESI, m/z): 420.5 (M+H+).

Workup

  1. customisolated (17 mg, 26%) as a white solid

Sources & evidence

ORD record
ord-79879cb7ffd54021807ef2f3bc1b9797
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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