HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Aminomethyl)cyclopentan-1-ol--hydrogen chloride (1/1) → 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-hydroxy-cyclopentylmethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Aminomethyl)cyclopentan-1-ol--hydrogen chloride (1/1) | HCID 21109693 | — |
| Reactant | 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid | HCID 90203809 | — |
| Product | 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-hydroxy-cyclopentylmethyl)-amide | HCID 76284221 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 54, using 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42c) and 1-(aminomethyl)cyclopentanol hydrochloride (CAN 76066-27-8) as starting materials and isolated (71 mg, 63%) as a white solid; MS (ESI, m/z): 331.0 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-a5afc7e1dceb466985df8d139186b165 |
| Source note | uspto-grants-2016_08 |