Cyclohexanol, 1-(aminomethyl)-, hydrochloride (1:1) → HCID 76284222, compound

HRID 1480113Notes

Reaction equation

HRID 1480113 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][CH:15]3[CH2:17][CH2:16]3)=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.Cl.[NH2:19][CH2:20][C:21]1([OH:27])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>>[OH:27][C:21]1([CH2:20][NH:19][C:10]([C:7]2[CH:6]=[C:5]([O:13][CH2:14][CH:15]3[CH2:17][CH2:16]3)[C:4]([CH:1]3[CH2:2][CH2:3]3)=[CH:9][N:8]=2)=[O:12])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 3084332Cyclohexanol, 1-(aminomethyl)-, hydrochloride (1:1)HCID 902038095-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 76284222HCID 76284222, compound

Procedure

The title compound was synthesized in analogy to Example 54, using 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42c) and 1-(aminomethyl)cyclohexanol hydrochloride (CAN 19968-85-5) as starting materials and isolated (70.5 mg, 58%) as a white solid; MS (ESI, m/z): 345.1 (M+H+).

Workup

  1. customisolated (70.5 mg, 58%) as a white solid

Sources & evidence

ORD record
ord-c67d8e81b6ae43bf96fc7d97151e9a03
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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