1-Amino-2-butanol → HCID 76283958, compound

HRID 1480114Notes

Reaction equation

HRID 1480114 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][CH:15]3[CH2:17][CH2:16]3)=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[NH2:18][CH2:19][CH:20]([OH:23])[CH2:21][CH3:22]>>[OH:23][CH:20]([CH2:21][CH3:22])[CH2:19][NH:18][C:10]([C:7]1[CH:6]=[C:5]([O:13][CH2:14][CH:15]2[CH2:17][CH2:16]2)[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:12]

Participants

3

Reactant 2

HCID 261071-Amino-2-butanolHCID 902038095-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 76283958HCID 76283958, compound

Procedure

The title compound was synthesized in analogy to Example 54, using 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42c) and 1-aminobutan-2-ol (CAN 13552-21-1) as starting materials and isolated (65 mg, 32%) as colorless oil; MS (ESI, m/z): 305.5 (M+H+).

Workup

  1. customisolated (65 mg, 32%) as colorless oil

Sources & evidence

ORD record
ord-b4c88b0e19c543a2aeb1565cf610980d
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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