2-Propanol, 1-amino-2-methyl- → HCID 76284220, compound

HRID 1480115Notes

Reaction equation

HRID 1480115 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][CH:15]3[CH2:17][CH2:16]3)=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[NH2:18][CH2:19][C:20]([CH3:23])([OH:22])[CH3:21]>>[OH:22][C:20]([CH3:23])([CH3:21])[CH2:19][NH:18][C:10]([C:7]1[CH:6]=[C:5]([O:13][CH2:14][CH:15]2[CH2:17][CH2:16]2)[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:12]

Participants

3

Reactant 2

HCID 951022-Propanol, 1-amino-2-methyl-HCID 902038095-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 76284220HCID 76284220, compound

Procedure

The title compound was synthesized in analogy to Example 54, using 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42c) and 1-amino-2-methylpropan-2-ol (CAN 2854-16-2) as starting materials and isolated (59 mg, 65%) as colorless oil; MS (ESI, m/z): 305.5 (M+H+).

Workup

  1. customisolated (59 mg, 65%) as colorless oil

Sources & evidence

ORD record
ord-66371da1ff924f989b71523dcbc16f4f
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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