化工社化工社 化学情報印刷レポート · 研究参考用
(2S)-1,1,1-Trifluoropropan-2-ol → 5-Cyclopropyl-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid (3-carbamoylmethyl-oxetan-3-yl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2S)-1,1,1-Trifluoropropan-2-ol | HCID 6999971 | — |
| 反応物 | 4-Chloro-5-cyclopropyl-pyridine-2-carboxylic acid (3-carbamoylmethyl-oxetan-3-yl)-amide | HCID 90214923 | — |
| 生成物 | 5-Cyclopropyl-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid (3-carbamoylmethyl-oxetan-3-yl)-amide | HCID 90214919 | — |
反応手順
The title compound was synthesized in analogy to Example 63c, using 4-Chloro-5-cyclopropyl-pyridine-2-carboxylic acid (3-carbamoylmethyl-oxetan-3-yl)-amide (Example 63b) and (S)-1,1,1-trifluoropropan-2-ol (CAN 3539-97-7) as starting materials and isolated (9 mg, 18%) as light brown solid; MS (ESI, m/z): 388.0 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09409866B2 |
| 出典データセット | uspto-grants-2016_08 |
| ORD ID | ord-204a3b1b3ab9441ebd7d2a5fbe711db2 |
| 出典メモ | uspto-grants-2016_08 |