HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R)-1,1,1-trifluoropropan-2-ol → 5-Cyclopropyl-4-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2R)-1,1,1-trifluoropropan-2-ol | HCID 6993809 | — |
| Reactant | 4-Chloro-5-cyclopropylpicolinic acid | HCID 90203520 | — |
| Product | 5-Cyclopropyl-4-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid | HCID 90204578 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 68a, using 4-Chloro-5-cyclopropyl-pyridine-2-carboxylic acid (Example 48b) and (R)-1,1,1-trifluoropropan-2-ol (CAN 17628-73-8) as starting materials and isolated (231 mg, 41%) as light brown solid; MS (ESI, m/z): 276.5 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-e3ca0b7e14d74101bc53e80b0f6d74dc |
| Source note | uspto-grants-2016_08 |