3,3-Difluoroazetidine hydrochloride → HCID 76283702, compound

HRID 1480135Notes

Reaction equation

HRID 1480135 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.Cl.[F:20][C:21]1([F:25])[CH2:24][NH:23][CH2:22]1>>[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([N:23]3[CH2:24][C:21]([F:25])([F:20])[CH2:22]3)=[O:12])=[N:8][CH:9]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 27582473,3-Difluoroazetidine hydrochlorideHCID 902036745-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 76283702HCID 76283702, compound

Procedure

The title compound was synthesized in analogy to Example 63b, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 48c) and 3,3-difluoroazetidine hydrochloride (CAN 288315-03-7) as starting materials and isolated (21 mg, 37%) as colorless oil; MS (ESI, m/z): 337.4 (M+H+).

Workup

  1. customisolated (21 mg, 37%) as colorless oil

Sources & evidence

ORD record
ord-a4c5f73da2424ad5837123b420d3c4d2
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

Loading…