2-amino-2,4-dimethylpentanamide → HCID 76283449, compound

HRID 1480147Notes

Reaction equation

HRID 1480147 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[NH2:19][C:20]([CH3:28])([CH2:24][CH:25]([CH3:27])[CH3:26])[C:21]([NH2:23])=[O:22]>>[C:21]([C:20]([NH:19][C:10]([C:7]1[CH:6]=[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:12])([CH3:28])[CH2:24][CH:25]([CH3:27])[CH3:26])(=[O:22])[NH2:23]

Participants

3

Reactant 2

HCID 140378232-amino-2,4-dimethylpentanamideHCID 902036745-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 76283449HCID 76283449, compound

Procedure

The title compound was synthesized in analogy to Example 23b, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 48c) and 2-amino-2,4-dimethylpentanamide (CAN 113509-60-7) as starting materials and isolated (41 mg, 32%) as a white solid; MS (ESI, m/z): 388.2 (M+H+).

Workup

  1. customisolated (41 mg, 32%) as a white solid

Sources & evidence

ORD record
ord-de458cb07d6c401b9a080584740de204
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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