HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3-aminooxetan-3-yl)-N,N-dimethylacetamide → 5-Chloro-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-dimethylcarbamoylmethyl-oxetan-3-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3-aminooxetan-3-yl)-N,N-dimethylacetamide | HCID 84107679 | — |
| Reactant | 5-Chloro-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid | HCID 90204014 | — |
| Product | 5-Chloro-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (3-dimethylcarbamoylmethyl-oxetan-3-yl)-amide | HCID 76283447 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 23b, using 5-Chloro-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 24c) and 2-(3-Amino-oxetan-3-yl)-N,N-dimethyl-acetamide as starting materials and isolated (4 mg, 5%) as colorless oil; MS (ESI, m/z): 396.4 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-a71a5d13ba444a73962824555d8d4637 |
| Source note | uspto-grants-2016_08 |