HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-2,4,4-trimethylpentanenitrile → 5-Bromo-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (1-cyano-1,3,3-trimethyl-butyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-2,4,4-trimethylpentanenitrile | HCID 21431348 | — |
| Reactant | 5-Bromo-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid | HCID 90204121 | — |
| Product | 5-Bromo-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (1-cyano-1,3,3-trimethyl-butyl)-amide | HCID 118554274 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 78e, using 5-Bromo-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 78d) and 2-amino-2,4,4-trimethylpentanenitrile (CAN 65260-84-6) as starting materials and isolated (643 mg, 87%) as a yellow oil; MS (ESI, m/z): 422.3 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-069444a52e8949a8acf4c0eb1b418c23 |
| Source note | uspto-grants-2016_08 |