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2-Amino-3-methanesulfonyl-2-methyl-propionitrile → 5-Bromo-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid (methanesulfonylmethyl-methyl-cyano-methyl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-3-methanesulfonyl-2-methyl-propionitrile | HCID 90203372 | — |
| 反応物 | 5-Bromo-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid | HCID 90203550 | — |
| 生成物 | 5-Bromo-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid (methanesulfonylmethyl-methyl-cyano-methyl)-amide | HCID 118554184 | — |
反応手順
The title compound was synthesized in analogy to Example 78e, using 5-Bromo-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid (Example 96d) and 2-Amino-3-methanesulfonyl-2-methyl-propionitrile (Example 80a) as starting materials and isolated (690 mg, 50%) as a yellow oil; MS (ESI, m/z): 458.3 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09409866B2 |
| 出典データセット | uspto-grants-2016_08 |
| ORD ID | ord-79ca9f89069d4e1aa3ef20dfc74ead25 |
| 出典メモ | uspto-grants-2016_08 |